Actually, Juno runs the risk of being compared to both Knocked Up and Napoleon Dynamite. The former, you know, the whole pregnancy thing. The film’s small-town locale, often-static camerawork, and stylized dialogue will invite comparisons to the latter. Still, that’s all surface, as Juno is a distinct creation.
Right away, Juno decides to terminate her pregnancy, which is not necessarily a comedic goldmine. Although, when she calls the clinic and says “I’d like to procure a hasty abortion”, that’s actually pretty funny. For reasons I’d rather not spoil she decides to carry the baby to term and find a family to adopt it. (In a nicely cynical touch, that’s how Juno refers to the fetus – “it”.)